Olin Hall 214
Ph.D., Chemistry, University of California, Irvine
B.S., Chemistry, Hope College
Dr. Adam Maley earned a B.S. in Chemistry (ACS certified) from Hope College in 2012. During his time at Hope, he conducted analytical and nuclear chemistry research with Prof. Graham Peaslee. In 2018, Dr. Maley earned his Ph.D. in Chemistry from the University of California, Irvine, where he worked in the laboratory of Prof. Robert Corn. Dr. Maley’s thesis research focused on developing new analytical techniques for characterizing single polymer and protein nanoparticles using Surface Plasmon Resonance (SPR) Imaging Microscopy. While at UC Irvine, Dr. Maley was selected as a Pedagogical Fellow and received training in advanced pedagogy. Through this program, he also designed and facilitated a series of workshops for new teaching assistants in the UCI Chemistry Department. After receiving his Ph.D., Dr. Maley moved to Boston, MA to work as a postdoctoral research fellow in the laboratory of Prof. David Walt at Brigham and Women’s Hospital, the Wyss Institute at Harvard University, and Harvard Medical School. His research in Prof. Walt’s lab focused on developing single-molecule assays using Single Molecule Array (Simoa) technology, and adapting the technology for point-of-care diagnostics. He also used the Simoa technology to develop ultrasensitive diagnostic tests for neonatal sepsis, as well as single-molecule serology and antigen assays for COVID-19. In 2019, Hope College awarded Dr. Maley with a 10 Under 10 Emerging Leader Alumni Award. In Fall 2020, Dr. Maley joined the Mund-Lagowski Department of Chemistry and Biochemistry as an Assistant Professor.
Dr. Maley’s primary teaching responsibilities include:
General Chemistry I (CHM 110)
Analytical Chemistry Lecture and Laboratory (CHM 326)
Instrumental Analysis Lecture and Laboratory (CHM 420/520)
The goal of research in the Maley lab is to develop new biologically inspired functional materials, study the fundamental properties and chemistry of these new materials, and use these materials to drive development of new technology in sensing and medical diagnostics. We interface the tools of materials chemistry and analytical chemistry to accomplish these goals.
Area 1: Design and synthesis of functional materials, including stimuli-responsive hydrogels, magnetic nanomaterials, and plasmonic nanomaterials. We are developing these materials primarily for applications in sensor development, drug delivery, and for analyte capture & manipulation.
Area 2: Use of analytical techniques to study the fundamental properties and chemistry of functional materials. Techniques include dynamic light scattering (DLS), fluorescence spectroscopy, surface plasmon resonance spectroscopy (SPR), scanning electron microscopy (SEM), and various single molecule techniques.
Area 3: Development of new technologies to advance the science of sensors and diagnostics. Our goal is to use polymer, plasmonic, and magnetic nanomaterials to develop new sensors in two areas: (1) simple, inexpensive sensors for point-of-care diagnostics and (2) single molecule sensors for ultrasensitive diagnostics.
T. Gilboa, A. M. Maley, A. F. Ogata, C. Wu, and D. R. Walt. Sequential Protein Capture in Multiplex Single Molecule Arrays: A Strategy for Eliminating Assay Cross-Reactivity. Advanced Healthcare Materials 2021, 10, 2001111.
A. M. Maley, P. M. Garden, and D. R. Walt. Simplified Digital Enzyme-linked Immunosorbent Assay Using Tyramide Signal Amplification and Fibrin Hydrogels. ACS Sensors 2020, 5, 3037-3042.
A. F. Ogata, A. M. Maley, C. Wu, T. Gilboa, M. Norman, R. Lazarovits, C. P. Mao, G. Newton, M. Chang, K. Nguyen, M. Kamkaew, Q. Zhu, T. E. Gibson, E. T. Ryan, R. C. Charles, W. A. Marasco, and D. R. Walt. Ultra-Sensitive Serial Profiling of SARS-CoV-2 Antigens and Antibodies in Plasma to Understand Disease Progression in COVID-19 Patients with Severe Disease. Clinical Chemistry 2020, 66, 1562-1672.
M. Norman, T. Gilboa, A. F. Ogata, A. M. Maley, L. Cohen, E. L. Busch, R. Lazarovits, C. P. Mao, Y. Cai, J. Zhang, J. E. Feldman, B. M. Hauser, T. M. Caradonna, B. Chen, A. G. Schmidt, G. Alter, R. C. Charles, E. T. Ryan, and D. R. Walt. Ultrasensitive High-Resolution Profiling of Early Seroconversion in Patients with COVID-19. Nature Biomedical Engineering 2020, 4, 1180-1187.
C. Wu, A. M. Maley, and D. R. Walt. Single-Molecule Measurements in Microwells for Clinical Applications. Critical Reviews in Clinical Laboratory Sciences 2020, 57, 270-290.
B. M. Matthews, A. M. Maley, K. M. Kartub, and R. M. Corn. Characterizing the Incorporation of DNA into Single NIPAm Hydrogel Nanoparticles with Surface Plasmon Resonance Imaging Measurements. The Journal of Physical Chemistry C 2019, 123, 6090-6096.
A. M. Maley, G. J. Lu, M. G. Shapiro, and R. M. Corn. Characterizing Single Polymeric and Protein Nanoparticles with Surface Plasmon Resonance Imaging Measurements. ACS Nano 2017, 11, 7447-7456.
S. So, H. W. M. Fung, K. Kartub, A. M. Maley, and R. M. Corn. Fabrication of PEDOT Nanocone Arrays with Electrochemically Modulated Broadband Antireflective Properties. The Journal of Physical Chemistry Letters 2017, 8, 576-579.
L. Viitala, A. M. Maley, H. W. M. Fung, R. M. Corn, T. Viitala, and L. Murtomaki. Surface Plasmon Resonance Imaging Microscopy of Liposomes and Liposome-Encapsulated Gold Nanoparticles. The Journal of Physical Chemistry C 2016, 120, 25958-25966.
A. M. Maley, Y. Terada, S. Onogi, K. J. Shea, Y. Miura, and R. M. Corn. Measuring Protein Binding to Individual Hydrogel Nanoparticles with Single-Nanoparticle Surface Plasmon Resonance Imaging Microscopy. The Journal of Physical Chemistry C 2016, 120, 16843-16849.
A. M. Maley, K. A. Falk, L. Hoover, E. B. Earlywine, M. D. Seymour, P. A. DeYoung, A. Blum, H. M. Stapleton, and G. F. Peaslee. Detection of Halogenated Flame Retardants in Polyurethane Foam by Particle Induced X-ray Emission. Nuclear Instruments and Methods in Physics Research B 2015, 358, 21-25.